Student and Faculty Publications

Publication Date

4-1-2024

Journal

Leukemia

Abstract

Resistance to apoptosis in acute myeloid leukemia (AML) cells causes refractory or relapsed disease, associated with dismal clinical outcomes. Ferroptosis, a mode of non-apoptotic cell death triggered by iron-dependent lipid peroxidation, has been investigated as potential therapeutic modality against therapy-resistant cancers, but our knowledge of its role in AML is limited. We investigated ferroptosis in AML cells and identified its mitochondrial regulation as a therapeutic vulnerability. GPX4 knockdown induced ferroptosis in AML cells, accompanied with characteristic mitochondrial lipid peroxidation, exerting anti-AML effects in vitro and in vivo. Electron transport chains (ETC) are primary sources of coenzyme Q

Keywords

Humans, Ferroptosis, Mitochondria, Lipids, Leukemia, Myeloid, Acute, Peptide Hydrolases

Comments

This article has been corrected. See Leukemia. 2024 March 08; : .

Supplementary Materials

PMID: 38148395

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