
Faculty, Staff and Student Publications
Publication Date
2-1-2024
Journal
eJHaem
Abstract
The simultaneous detection of BCR::ABL1 and JAK2 V617F was rarely reported and their clonal relationship and dynamic clonal shift were not characterized. Here, we described a unique case with the initial presentation as JAK2 V617F+ primary myelofibrosis, followed by the emergence of BCR::ABL1+ chronic myeloid leukemia. The patient then developed BCR::ABL1+ B-lymphoblastic leukemia. Treatment for B-lymphoblastic leukemia prompted a regression to the state of primary myelofibrosis. In light of these observations, we proposed a clonal evolution model for this case.
Keywords
BCR::ABL1 + B‐ALL, clonal evolution, CML, JAK2 V617F, PMF
PMID
38406521
PMCID
PMC10887360
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