Advances in Understanding Cancer-Associated Neurogenesis and Its Implications on the Neuroimmune Axis in Cancer

Authors

Ismail Yaman
Didem Ağaç Çobanoğlu
Tongxin Xie
Yi Ye
Moran Amit

Publication Date

11-1-2022

Journal

Pharmacology & Therapeutics

Abstract

Nerves and immunologic mediators play pivotal roles in body homeostasis by interacting with each other through diverse mechanisms. The spread of nerves in the tumor microenvironment increases tumor cell proliferation and disease progression, and this correlates with poor patient outcomes. The effects of sympathetic and parasympathetic nerves on cancer regulation are being investigated. Recent findings demonstrate the possibility of developing therapeutic strategies that target the tumor microenvironment and its components such as immune cells, neurotransmitters, and extracellular vesicles. Therefore, examining and understanding the mechanisms and pathways associated with the sympathetic and parasympathetic nervous systems, neurotransmitters, cancer-derived mediators and their interactions with the immune system in the tumor microenvironment may lead to the development of new cancer treatments. This review discusses the effects of nerve cells, immune cells, and cancer cells have on each other that regulate neurogenesis, cancer progression, and dissemination.

Keywords

Humans, Neuroimmunomodulation, Neoplasms, Tumor Microenvironment, Neurogenesis, Neurotransmitter Agents, Cancer, Neuroimmune axis, Sympathetic nervous system, Parasympathetic nervous system, Tumor microenvironment

DOI

10.1016/j.pharmthera.2022.108199

PMID

35490859

PMCID

PMC9991830

PubMedCentral® Posted Date

3-7-2023

PubMedCentral® Full Text Version

Author MSS

Published Open-Access

yes