Faculty, Staff and Student Publications
Publication Date
9-17-2024
Journal
Cell Reports Medicine
Abstract
Metabolic dysfunction-associated steatotic liver disease (MASLD) prevalence is increasing annually and affects over a third of US adults. MASLD can progress to metabolic dysfunction-associated steatohepatitis (MASH), characterized by severe hepatocyte injury, inflammation, and eventual advanced fibrosis or cirrhosis. MASH is predicted to become the primary cause of liver transplant by 2030. Although the etiology of MASLD/MASH is incompletely understood, dysregulated fatty acid oxidation is implicated in disease pathogenesis. Here, we develop a method for estimating hepatic β-oxidation from the metabolism of [D
Keywords
Animals, Oxidation-Reduction, Disease Models, Animal, Magnetic Resonance Imaging, Liver, Mice, Lipid Metabolism, Fatty Liver, Mice, Inbred C57BL, Diet, High-Fat, Male, Fatty Acids
DOI
10.1016/j.xcrm.2024.101714
PMID
39241774
PMCID
PMC11525016
PubMedCentral® Posted Date
9-5-2024
PubMedCentral® Full Text Version
Post-print
Graphical Abstract
Published Open-Access
yes
Included in
Bioinformatics Commons, Biological Phenomena, Cell Phenomena, and Immunity Commons, Biomedical Informatics Commons, Medical Cell Biology Commons, Oncology Commons