Faculty, Staff and Student Publications
Publication Date
5-1-2022
Journal
Brain, Behavior, & Immunity - Health
Abstract
Bipolar disorder (BD) is a severe psychiatric disorder affecting approximately 1-3% of the population and characterized by a chronic and recurrent course of debilitating symptoms. An increasing focus has been directed to discover and explain the function of Blood-Brain Barrier (BBB) integrity and its association with a number of psychiatric disorders; however, there has been limited research in the role of BBB integrity in BD. Multiple pathways may play crucial roles in modulating BBB integrity in BD, such as inflammation, insulin resistance, and alterations of neuronal plasticity. In turn, BBB impairment is hypothesized to have a significant clinical impact in BD patients. Based on the high prevalence of medical and psychiatric comorbidities in BD and a growing body of evidence linking inflammatory and neuroinflammatory mechanisms to the disorder, recent studies have suggested that BBB dysfunction may play a key role in BD's pathophysiology. In this comprehensive narrative review, we aim to discuss studies investigating biological markers of BBB in patients with BD, mechanisms that modulate BBB integrity, their clinical implications on patients, and key targets for future development of novel therapies.
Keywords
Bipolar disorder, Blood-brain barrier, Inflammation, Claudin, Tight junction, Mania
DOI
10.1016/j.bbih.2022.100441
PMID
35308081
PMCID
PMC8924633
PubMedCentral® Posted Date
3-5-2022
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Included in
Behavioral Medicine Commons, Bioinformatics Commons, Biomedical Informatics Commons, Medical Sciences Commons, Mental and Social Health Commons, Oncology Commons