Antibody-Conjugated Polymersomes with Encapsulated Indocyanine Green J-Aggregates and High Near-Infrared Absorption for Molecular Photoacoustic Cancer Imaging

Authors

Mohammed R Kawelah
Sangheon Han
Ceren Atila Dincer
Jongyeong Jeon
Joel Brisola
Aasim F Hussain
Ananthakrishnan S Jeevarathinam
Richard Bouchard
Alexander E Marras
Thomas M Truskett
Konstantin V Sokolov
Keith P Johnston

Publication Date

2-7-2024

Journal

ACS Applied Materials & Interfaces Journal

Abstract

Imaging plays a critical role in all stages of cancer care from early detection to diagnosis, prognosis, and therapy monitoring. Recently, photoacoustic imaging (PAI) has started to emerge into the clinical realm due to its high sensitivity and ability to penetrate tissues up to several centimeters deep. Herein, we encapsulated indocyanine green J (ICGJ) aggregate, one of the only FDA-approved organic exogenous contrast agents that absorbs in the near-infrared range, at high loadings up to ∼40% w/w within biodegradable polymersomes (ICGJ-Ps) composed of poly(lactide-

Keywords

Indocyanine Green, Contrast Media, Spectrum Analysis, Molecular Imaging, Immunoconjugates, ErbB Receptors, Photoacoustic Techniques, Photoacoustic imaging, indocyanine green, J-aggregates, polymersomes, breast cancer

DOI

10.1021/acsami.3c16584

PMID

38270979

PMCID

PMC11246536

PubMedCentral® Posted Date

2-7-2025

PubMedCentral® Full Text Version

Author MSS

Published Open-Access

yes