Faculty, Staff and Student Publications
Publication Date
1-31-2023
Journal
Biomolecules
Abstract
Lnc-uc.147, a long non-coding RNA derived from a transcribed ultraconserved region (T-UCR), was previously evidenced in breast cancer. However, the role of this region in other tumor types was not previously investigated. The present study aimed to investigate lnc-uc.147 in different types of cancer, as well as to suggest lnc-uc.147 functional and regulation aspects. From solid tumor datasets analysis of The Cancer Genome Atlas (TCGA), deregulated lnc-uc.147 expression was associated with the histologic grade of hepatocellular carcinoma, and with the tumor stage of clear cell renal and gastric adenocarcinoma. Considering the epidemiologic relevance of liver cancer, silencing lnc-uc.147 reduced the viability and clonogenic capacity of HepG2 cell lines. Additionally, we suggest a relation between the transcription factor TEAD4 and lnc-uc.147 in liver and breast cancer cells.
Keywords
Humans, Female, Conserved Sequence, Carcinoma, Hepatocellular, RNA, Long Noncoding, Carcinoma, Renal Cell, Kidney Neoplasms, Breast Neoplasms, Gene Expression Regulation, Neoplastic, TEA Domain Transcription Factors, lnc-uc.147, uc.147, T-UCRs, liver cancer, lncRNAs, TEA domain transcription factor 4
DOI
10.3390/biom13020265
PMID
36830634
PMCID
PMC9953473
PubMedCentral® Posted Date
1-31-2023
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Included in
Bioinformatics Commons, Biomedical Informatics Commons, Digestive System Diseases Commons, Gastroenterology Commons, Hemic and Lymphatic Diseases Commons, Hepatology Commons, Medical Molecular Biology Commons, Oncology Commons