Faculty, Staff and Student Publications

Publication Date

1-31-2023

Journal

Biomolecules

Abstract

Lnc-uc.147, a long non-coding RNA derived from a transcribed ultraconserved region (T-UCR), was previously evidenced in breast cancer. However, the role of this region in other tumor types was not previously investigated. The present study aimed to investigate lnc-uc.147 in different types of cancer, as well as to suggest lnc-uc.147 functional and regulation aspects. From solid tumor datasets analysis of The Cancer Genome Atlas (TCGA), deregulated lnc-uc.147 expression was associated with the histologic grade of hepatocellular carcinoma, and with the tumor stage of clear cell renal and gastric adenocarcinoma. Considering the epidemiologic relevance of liver cancer, silencing lnc-uc.147 reduced the viability and clonogenic capacity of HepG2 cell lines. Additionally, we suggest a relation between the transcription factor TEAD4 and lnc-uc.147 in liver and breast cancer cells.

Keywords

Humans, Female, Conserved Sequence, Carcinoma, Hepatocellular, RNA, Long Noncoding, Carcinoma, Renal Cell, Kidney Neoplasms, Breast Neoplasms, Gene Expression Regulation, Neoplastic, TEA Domain Transcription Factors, lnc-uc.147, uc.147, T-UCRs, liver cancer, lncRNAs, TEA domain transcription factor 4

DOI

10.3390/biom13020265

PMID

36830634

PMCID

PMC9953473

PubMedCentral® Posted Date

1-31-2023

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes

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