Non-Coding RNAs in Peritoneal Carcinomatosis: From Bench to Bedside

Authors

Julia Bohosova
Nida Sarosh Ashraf
Ondrej Slaby
George A Calin

Publication Date

8-25-2024

Journal

Cancers

Abstract

Peritoneal carcinomatosis represents an advanced stage of tumors within the peritoneal cavity. Once considered an incurable terminal cancer metastasis, contemporary medicine is on the hunt for certain potentially curative options alongside the present day’s palliative disease management. However, for most patients, peritoneal carcinomatosis continues to pose a fatal late-stage prognosis with a grim future outlook. Over the past two decades, non-coding RNAs have garnered significant attention due to their undeniable significance in regulating cellular processes across all levels. Disruption of the intricate regulation led by non-coding RNAs has been demonstrated to have a substantial impact on various human diseases, particularly in cancer, including solid tumors originating from the organs of the peritoneal cavity. This review aims to offer a comprehensive overview of the current state of knowledge in the under-researched field of peritoneal carcinomatosis, focusing specifically on the role of non-coding RNAs in the development of this condition and delineating potential avenues for future research.

Keywords

peritoneal carcinomatosis, non-coding RNA, miRNA, ascites, exosomes

DOI

10.3390/cancers16172961

PMID

39272819

PMCID

PMC11394633

PubMedCentral® Posted Date

8-25-2024

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes