
Faculty, Staff and Student Publications
Publication Date
9-1-2024
Journal
Trends in Cancer
Abstract
Noncoding RNAs, especially miRNAs, play a pivotal role in cancer initiation and metastasis, underscoring their susceptibility to precise modulation via small molecule inhibitors. This review examines the innovative strategy of targeting oncogenic miRNAs with small drug-like molecules, an approach that can reshape the cancer treatment landscape. We review the current understanding of the multifaceted roles of miRNAs in oncogenesis, highlighting emerging therapeutic paradigms that have the potential to expand cancer treatment options. As research on small molecule inhibitors of miRNA is still in its early stages, ongoing investigative efforts and the development of new technologies and chemical matter are essential to fulfill the significant potential of this innovative approach to cancer treatment.
Keywords
Humans, MicroRNAs, Neoplasms, Precision Medicine, Molecular Targeted Therapy, Gene Expression Regulation, Neoplastic, Antineoplastic Agents, Small Molecule Libraries, Animals, cancer, miRNAs, noncoding RNAs, small molecules, therapy
DOI
10.1016/j.trecan.2024.06.006
PMID
39107162
PMCID
PMC11961049
PubMedCentral® Posted Date
4-1-2025
PubMedCentral® Full Text Version
Author MSS
Published Open-Access
yes
Included in
Bioinformatics Commons, Biomedical Informatics Commons, Genetic Phenomena Commons, Medical Genetics Commons, Oncology Commons