Small Molecules Targeting microRNAs: New Opportunities and Challenges in Precision Cancer Therapy

Authors

Ancuta Jurj
Beatrice Fontana
Gabriele Varani
George A Calin

Publication Date

9-1-2024

Journal

Trends in Cancer

Abstract

Noncoding RNAs, especially miRNAs, play a pivotal role in cancer initiation and metastasis, underscoring their susceptibility to precise modulation via small molecule inhibitors. This review examines the innovative strategy of targeting oncogenic miRNAs with small drug-like molecules, an approach that can reshape the cancer treatment landscape. We review the current understanding of the multifaceted roles of miRNAs in oncogenesis, highlighting emerging therapeutic paradigms that have the potential to expand cancer treatment options. As research on small molecule inhibitors of miRNA is still in its early stages, ongoing investigative efforts and the development of new technologies and chemical matter are essential to fulfill the significant potential of this innovative approach to cancer treatment.

Keywords

Humans, MicroRNAs, Neoplasms, Precision Medicine, Molecular Targeted Therapy, Gene Expression Regulation, Neoplastic, Antineoplastic Agents, Small Molecule Libraries, Animals, cancer, miRNAs, noncoding RNAs, small molecules, therapy

DOI

10.1016/j.trecan.2024.06.006

PMID

39107162

PMCID

PMC11961049

PubMedCentral® Posted Date

4-1-2025

PubMedCentral® Full Text Version

Author MSS

Published Open-Access

yes