The miR-17-92 Cluster in Cardiac Health and Disease

Authors

Yuhan Cao
Mingjie Zheng
Maham A Sewani
Jun Wang

Publication Date

1-1-2024

Journal

Birth Defects Research

Abstract

MicroRNAs (miRs) are small noncoding RNAs that play important roles in both physiological and pathological processes through post-transcriptional regulation. The miR-17-92 cluster includes six individual members: miR-17, miR-18a, miR-19a, miR-19b-1, miR-20a, and miR-92a-1. The miR-17-92 cluster has been extensively studied and reported to broadly function in cancer biology, immunology, neurology, pulmonology, and cardiology. This review focuses on its roles in heart development and cardiac diseases. We briefly introduce the nature of the miR-17-92 cluster and its crucial roles in both normal development and the pathogenesis of various diseases. We summarize the recent progress in understanding the versatile roles of miR-17-92 during cardiac development, regeneration, and aging. Additionally, we highlight the indispensable roles of the miR-17-92 cluster in pathogenesis and therapeutic potential in cardiac birth defects and adult cardiac diseases.

Keywords

Humans, Gene Expression Regulation, Neoplastic, MicroRNAs, Heart, Heart Diseases, miR-17-92, non-coding RNAs, cardiac development, cardiac diseases, cardiac regeneration

DOI

10.1002/bdr2.2273

PMID

37984445

PMCID

PMC11418803

PubMedCentral® Posted Date

1-1-2025

PubMedCentral® Full Text Version

Author MSS

Published Open-Access

yes