Current State and Future Directions of Genomic Medicine in Aortic Dissection: A Path to Prevention and Personalized Care

Authors

Alana C Cecchi
Madeline Drake
Chrisanne Campos
Jake Howitt
Jonathan Medina
Scott M Damrauer
Sherene Shalhub
Dianna M Milewicz
Aortic Dissection Collaborative

Publication Date

3-1-2022

Journal

Seminars in Vascular Surgery

Abstract

Aortic dissection confers high mortality and morbidity rates despite advances in treatment, impacts quality of life, and contributes immense burden to the healthcare system globally. Efforts to prevent aortic dissection through screening and management of modifiable risk factors and early detection of aneurysms should incorporate genomic information, as it is integral to stratifying risk. However, effective integration of genomic-guided risk assessment into clinical practice will require addressing implementation barriers that currently permeate our healthcare systems. The Aortic Dissection Collaborative was established to define aortic dissection research priorities through patient engagement. Using a collaborative patient-centered feedback model, our Genomic Medicine Working Group identified related research priorities that could be investigated by pragmatic interventional studies aimed at aortic dissection prevention, utilization of genomic information to improve patient outcomes, and access to genomic medicine services. Further research is also needed to identify the genomic, lifestyle, and environmental risk factors that contribute to aortic dissection so these data can be incorporated into future comparative effectiveness studies to prevent aortic dissection.

Keywords

Aortic Dissection, Genomic Medicine, Humans, Quality of Life, Risk Assessment, Risk Factors

DOI

10.1053/j.semvascsurg.2022.02.003

PMID

35501041

PMCID

PMC9258522

PubMedCentral® Posted Date

7-6-2022

PubMedCentral® Full Text Version

Author MSS

Published Open-Access

yes