
Faculty, Staff and Student Publications
Publication Date
6-21-2022
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abstract
Cell surface proteins play essential roles in various biological processes and are highly related to cancer development. They also serve as important markers for cell identity and targets for pharmacological intervention. Despite their great potentials in biomedical research, comprehensive functional analysis of cell surface proteins remains scarce. Here, with a de novo designed library targeting cell surface proteins, we performed in vivo CRISPR screens to evaluate the effects of cell surface proteins on tumor survival and proliferation. We found that
Keywords
Animals, Cell Proliferation, Genes, Tumor Suppressor, Hippo Signaling Pathway, Membrane Proteins, Mice, Neoplasms, Signal Transduction, Hippo, KIRREL, SAV1, CRISPR, integrated screens
DOI
10.1073/pnas.2121779119
PMID
35704761
PMCID
PMC9231494
PubMedCentral® Posted Date
6-15-2022
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Included in
Bioinformatics Commons, Biomedical Informatics Commons, Genetic Phenomena Commons, Medical Genetics Commons, Oncology Commons