Faculty, Staff and Student Publications
Publication Date
7-1-2022
Journal
American Journal of Physiology-Cell Physiology
Abstract
Syndecan-1 (SDC1, CD138) is one of the heparan sulfate proteoglycans and is essential for maintaining normal cell morphology, interacting with the extracellular and intracellular protein repertoire, as well as mediating signaling transduction upon environmental stimuli. The critical role of SDC1 in promoting tumorigenesis and metastasis has been increasingly recognized in various cancer types, implying a promising potential of utilizing SDC1 as a novel target for cancer therapy. This review summarizes the current knowledge on SDC1 structure and functions, including its role in tumor biology. We also discuss the highlights and limitations of current SDC1-targeted therapies as well as the obstacles in developing new therapeutic methods, offering our perspective on the future directions to target SDC1 for cancer treatment.
Keywords
Carcinogenesis, Cell Transformation, Neoplastic, Humans, Neoplasms, Signal Transduction, Syndecan-1, cancer, CD138, proteoglycan, syndecan-1, therapy
DOI
10.1152/ajpcell.00024.2022
PMID
35584326
PMCID
PMC9236862
PubMedCentral® Posted Date
5-18-2022
PubMedCentral® Full Text Version
Post-Print
Published Open-Access
yes
Included in
Bioinformatics Commons, Biological Phenomena, Cell Phenomena, and Immunity Commons, Biomedical Informatics Commons, Genetic Phenomena Commons, Medical Cell Biology Commons, Medical Genetics Commons, Oncology Commons