Faculty, Staff and Student Publications
Publication Date
6-19-2024
Abstract
The post-genomic era has ushered in the extensive application of epigenetic editing tools, allowing for precise alterations of gene expression. The use of reprogrammable editors that carry transcriptional corepressors has significant potential for long-term epigenetic silencing for the treatment of human diseases. The ideal scenario involves precise targeting of a specific genomic location by a DNA-binding domain, ensuring there are no off-target effects and that the process yields no genetic remnants aside from specific epigenetic modifications (i.e., DNA methylation). A notable example is a recent study on the mouse
Keywords
CpG islands in promoters, CpG-free segments, C2H2 zinc-finger arrays, DNA sequence-specific binding, DNA methylation, epigenetic reprogramming
DOI
10.3390/epigenomes8020023
PMID
38920624
PMCID
PMC11202855
PubMedCentral® Posted Date
6-19-2024
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Included in
Bioinformatics Commons, Biomedical Informatics Commons, Genetic Phenomena Commons, Medical Genetics Commons, Oncology Commons