Cell-Directed Aptamer Therapeutic Targeting for Cancers Including Those Within the Central Nervous System

Authors

Jun Wei
Renduo Song
Aria Sabbagh
Anantha Marisetty
Neal Shukla
Dexing Fang
Hinda Najem
Martina Ott
James Long
Lijie Zhai
Maciej S Lesniak
Charles David James
Leonidas Platanias
Michael Curran
Amy B Heimberger

Publication Date

1-1-2022

Journal

Oncoimmunology

Abstract

Osteopontin (OPN) is produced by tumor cells as well as by myeloid cells and is enriched in the tumor microenvironment (TME) of many cancers. Given the roles of OPN in tumor progression and immune suppression, we hypothesized that targeting OPN with aptamers that have high affinity and specificity could be a promising therapeutic strategy. Bi-specific aptamers targeting ligands for cellular internalization were conjugated to siRNAs to suppress OPN were created, and therapeutic leads were selected based on target engagement and

Keywords

Aptamers, Nucleotide, Breast Neoplasms, Central Nervous System, Female, Glioma, Humans, RNA, Small Interfering, Tumor Microenvironment, Osteopontin, nucleolin, aptamers, CpG ODN, siRNA, brain cancer, breast cancer, lung cancer

DOI

10.1080/2162402X.2022.2062827

PMID

35433114

PMCID

PMC9009928

PubMedCentral® Posted Date

4-13-2022

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes