Infiltration of Peripheral Immune Cells Into the Olfactory Bulb in a Mouse Model of Acute Nasal Inflammation

Authors

Hinami Asano
Sanae Hasegawa-Ishii
Ken Arae
Aki Obara
Geoffroy Laumet
Robert Dantzer
Atsuyoshi Shimada

Publication Date

7-15-2022

Journal

Journal of Neuroimmunology

Abstract

Chronic nasal inflammation induces robust olfactory bulb (OB) atrophy in mice. Here we examined initial events that occur in the OB after bilateral intranasal administration of lipopolysaccharide, focusing on the olfactory nerve fibers and meninges. We analyzed the time course of OB and meninges inflammation using histological and biochemical approaches. Within 12 h, we observed increased chemokine expression and transient infiltration of peripheral immune cells into the OB, resulting in the development of pro-inflammatory status in the OB. Meningeal immunity was activated. Resident microglia produced anti-inflammatory cytokines within 24 h. These could be the initial events that lead to OB atrophy.

Keywords

Animals, Atrophy, Disease Models, Animal, Inflammation, Lipopolysaccharides, Mice, Olfactory Bulb, Nasal inflammation, Olfactory nerve fibers, Peripheral immune cells, Meninges, Olfactory bulb, Resident microglia

DOI

10.1016/j.jneuroim.2022.577897

PMID

35661951

PMCID

PMC9903215

PubMedCentral® Posted Date

2-7-2023

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes