Faculty, Staff and Student Publications

Publication Date

1-1-2025

Journal

Leukemia Research Reports

Abstract

Delayed hemolytic transfusion reaction (DHTR) poses a significant challenge in patients receiving blood transfusions. This case report highlights the complexities of managing DHTR in a newly diagnosed chronic myelomonocytic leukemia (CMML) patient with clinically significant JKa and little c antibodies during induction chemotherapy. A 46-year-old woman with CMML-2 who presented for induction chemotherapy was found to have hemolytic anemia. Due to presence of JKa and little c antibodies, she required intensive monitoring and supportive care measures. The coexistence of JKa and little c antibodies complicates transfusion management and chemotherapy tolerance in CMML patients.

Keywords

Hemolytic transfusion reactions, CMML, Induction therapy

DOI

10.1016/j.lrr.2024.100485

PMID

39691506

PMCID

PMC11647623

PubMedCentral® Posted Date

11-28-2024

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes

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