
Faculty, Staff and Student Publications
Publication Date
1-1-2025
Journal
Leukemia Research Reports
Abstract
Delayed hemolytic transfusion reaction (DHTR) poses a significant challenge in patients receiving blood transfusions. This case report highlights the complexities of managing DHTR in a newly diagnosed chronic myelomonocytic leukemia (CMML) patient with clinically significant JKa and little c antibodies during induction chemotherapy. A 46-year-old woman with CMML-2 who presented for induction chemotherapy was found to have hemolytic anemia. Due to presence of JKa and little c antibodies, she required intensive monitoring and supportive care measures. The coexistence of JKa and little c antibodies complicates transfusion management and chemotherapy tolerance in CMML patients.
Keywords
Hemolytic transfusion reactions, CMML, Induction therapy
DOI
10.1016/j.lrr.2024.100485
PMID
39691506
PMCID
PMC11647623
PubMedCentral® Posted Date
11-28-2024
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Included in
Bioinformatics Commons, Biomedical Informatics Commons, Genetic Phenomena Commons, Hematology Commons, Hemic and Lymphatic Diseases Commons, Medical Genetics Commons, Oncology Commons