Recurrent Somatic Copy Number Alterations and Their Association with Oncogene Expression Levels in High-Grade Ovarian Serous Carcinoma

Authors

Hillary P Esplen
Richard K Yang
Awdhesh Kalia
Zhenya Tang
Guilin Tang
L Jeffrey Medeiros
Gokce A Toruner

Publication Date

11-10-2023

Journal

Life

Abstract

Somatic copy number alterations (SCNAs) are frequently observed in high-grade ovarian serous carcinoma (HGOSC). However, their impact on gene expression levels has not been systematically assessed. In this study, we explored the relationship between recurrent SCNA and gene expression using The Cancer Genome Atlas Pan Cancer dataset (OSC, TCGA, PanCancer Atlas) to identify cancer-related genes in HGOSC. We then investigated any association between highly correlated cancer genes and clinicopathological parameters, including age of diagnosis, disease stage, overall survival (OS), and progression-free survival (PFS). A total of 772 genes with recurrent SCNAs were observed. SCNA and mRNA expression levels were highly correlated for 274 genes; 24 genes were classified as a Tier 1 gene in the Cancer Gene Census in the Catalogue of Somatic Mutations in Cancer (CGC-COSMIC). Of these, 11 Tier 1 genes had highly correlated SCNA and mRNA expression levels:

Keywords

high-grade ovarian serous carcinoma, somatic copy number aberration, gene expression

DOI

10.3390/life13112192

PMID

38004332

PMCID

PMC10672014

PubMedCentral® Posted Date

11-10-2023

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes