Determinant of 30-Day Mortality of Pulmonary Legionellosis: Do Coinfections Matter?

Authors

Takahiro Matsuo
Sebastian Wurster
Ying Jiang
Jeffrey Tarrand
Scott E Evans
Dimitrios P Kontoyiannis

Publication Date

9-1-2024

Journal

Open Forum Infectious Diseases

Abstract

We retrospectively reviewed 64 cases of cancer with pulmonary legionellosis (Legionella pneumophila in 73%). Nearly all patients received Legionella-active antibiotics, yet 30-day mortality was 23%. Independent predictors of 30-day mortality were hyponatremia, bilateral lung involvement, and Sequential Organ Failure Assessment score ≥5. Lung coinfections were common (31%) but did not significantly increase mortality.

Keywords

cancer, coinfections, Legionella, mortality outcomes, pneumonia

DOI

10.1093/ofid/ofae529

PMID

39319087

PMCID

PMC11420677

PubMedCentral® Posted Date

9-12-2024

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes