The microRNA-183/96/182 Cluster Inhibits Lung Cancer Progression and Metastasis by Inducing an Interleukin-2-Mediated Antitumor CD8+ Cytotoxic T-Cell Response

Authors

Samrat T Kundu
B Leticia Rodriguez
Laura A Gibson
Amanda N Warner
Mabel G Perez
Rakhee Bajaj
Jared J Fradette
Caleb A Class
Luisa M Solis
Frank R Rojas Alvarez
Ignacio I Wistuba
Lixia Diao
Fengju Chen
Mohit Sachdeva
Jing Wang
David G Kirsch
Chad J Creighton
Don L Gibbons

Publication Date

5-1-2022

Journal

Genes Development

Abstract

Here, Kundu et al. investigated the role of the microRNA-183/96/182 cluster (m96cl) in lung cancer and used a novel conditional m96cl mouse to establish that loss of m96cl accelerated the growth of K-Ras mutant autochthonous lung adenocarcinomas. Overall, the authors identified a novel mechanistic role of the m96cl in the suppression of lung cancer growth and metastasis by inducing an IL2-mediated systemic CD8+ CTL immune response.

Keywords

Animals, CD8-Positive T-Lymphocytes, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Interleukin-2, Lung Neoplasms, Mice, MicroRNAs, T-Lymphocytes, Cytotoxic, Tumor Microenvironment, CD8+ T lymphocytes, CTL, tumor immune microenvironment, microRNA-183/96/182, antitumor immune response, interleukin-2, EMT, Zeb1, Foxf2, lung cancer

DOI

10.1101/gad.349321.121

PMID

35654454

PMCID

PMC9186390

PubMedCentral® Posted Date

5-1-2022

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes