Tumor-Associated Tractography Derived from High-Angular-Resolution Q-Space MRI May Predict Patterns of Cellular Invasion in Glioblastoma

Authors

Owen P Leary
John P Zepecki
Mattia Pizzagalli
Steven A Toms
David D Liu
Yusuke Suita
Yao Ding
Jihong Wang
Renjie He
Caroline Chung
Clifton D Fuller
Jerrold L Boxerman
Nikos Tapinos
Richard J Gilbert

Publication Date

10-30-2024

Journal

Cancers

Abstract

BACKGROUND: The invasion of glioblastoma cells beyond the visible tumor margin depicted by conventional neuroimaging is believed to mediate recurrence and predict poor survival. Radiomic biomarkers that are associated with the direction and extent of tumor infiltration are, however, non-existent.

METHODS: Patients from a single center with newly diagnosed glioblastoma (

RESULTS: In the principal enrollment cohort of patients with glioblastoma, all cases displayed tractography patterns with tumor-intersecting tract bundles extending into brain parenchyma, a phenotype which was reproduced in PDX mice as well as in a larger comparison cohort of glioblastoma patients (

CONCLUSIONS: QSI discriminates tumor-specific patterns of inter-voxel coherence believed to represent white matter pathways which may be susceptible to glioblastoma invasion. These findings may lay the groundwork for future work on therapeutic targeting, patient stratification, and prognosis in glioblastoma.

DOI

10.3390/cancers16213669

PMID

39518107

PMCID

PMC11544887

PubMedCentral® Posted Date

10-30-2024

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes