Faculty, Staff and Student Publications

Publication Date

9-1-2024

Journal

Nature Cell Biology

Abstract

Ferroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid peroxidation, has garnered substantial interest since this term was first coined in 2012. Recent years have witnessed remarkable progress in elucidating the detailed molecular mechanisms that govern ferroptosis induction and defence, with particular emphasis on the roles of heterogeneity and plasticity. In this Review, we discuss the molecular ecosystem of ferroptosis, with implications that may inform and enable safe and effective therapeutic strategies across a broad spectrum of diseases.

Keywords

Ferroptosis, Humans, Animals, Lipid Peroxidation, Signal Transduction, Reactive Oxygen Species, Iron

DOI

10.1038/s41556-024-01360-8

PMID

38424270

PMCID

PMC11650678

PubMedCentral® Posted Date

12-17-2024

PubMedCentral® Full Text Version

Author MSS

Published Open-Access

yes

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