Faculty, Staff and Student Publications
Publication Date
3-28-2025
Abstract
Gestational diabetes mellitus (GD)-induced gut dysbiosis in pregnant mothers may increase the risk of cognitive impairment and neurological disorders in both the mother and offspring as they age. Restoring gut balance could improve cognitive outcomes for both. Despite advancements in GD treatment, side effects have increased, and long-term neurocognitive impacts on offspring born to GD mothers remain underexplored. This study uses a GD mouse model, inducing pancreatic dysfunction in 3-month-old pregnant C57BL/6J mice with Streptozotocin. The efficacy and mechanism of the prebiotic phytocompound green leaf extract (
Keywords
Animals, Pregnancy, Female, Prebiotics, Diabetes, Gestational, Mice, Gastrointestinal Microbiome, Cognition, Mice, Inbred C57BL, Diabetes Mellitus, Experimental, Dysbiosis, Blood Glucose, Plant Extracts, Cognitive Dysfunction, Prenatal Exposure Delayed Effects, gestational diabetes, gut microbiota, dysbiosis, phytocompounds, prebiotics, maternal health, cognition
DOI
10.3390/ijms26073140
PMID
40243881
PMCID
PMC11988369
PubMedCentral® Posted Date
3-28-2025
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Included in
Biochemical Phenomena, Metabolism, and Nutrition Commons, Bioinformatics Commons, Biomedical Informatics Commons, Endocrinology, Diabetes, and Metabolism Commons, Gastroenterology Commons, Genetic Phenomena Commons, Medical Genetics Commons