A Genome-Wide Association Study Identified Novel Genetic Susceptibility Loci for Oral Cancer in Taiwan

Authors

Da-Tian Bau
Ting-Yuan Liu
Chia-Wen Tsai
Wen-Shin Chang
Jian Gu
Jai-Sing Yang
Liang-Chun Shih
Fuu-Jen Tsai

Publication Date

2-1-2023

Journal

International Journal of Molecular Sciences

Abstract

Taiwan has the highest incidence rate of oral cancer in the world. Although oral cancer is mostly an environmentally induced cancer, genetic factors also play an important role in its etiology. Genome-wide association studies (GWAS) have identified nine susceptibility regions for oral cancers in populations of European descent. In this study, we performed the first GWAS of oral cancer in Taiwan with 1529 cases and 44,572 controls. We confirmed two previously reported loci on the 6p21.33 (HLA-B) and 6p21.32 (HLA-DQ gene cluster) loci, highlighting the importance of the human leukocyte antigen and, hence, the immunologic mechanisms in oral carcinogenesis. The TERT-CLMPT1L locus on 5p15.33, the 4q23 ADH1B locus, and the LAMC3 locus on 9q34.12 were also consistent in the Taiwanese. We found two new independent loci on 6p21.32, rs401775 in SKIV2L gene and rs9267798 in TNXB gene. We also found two suggestive novel Taiwanese-specific loci near the TPRS1 gene on 8q23.3 and in the TMED3 gene on 15q25.1. This study identified both common and unique oral cancer susceptibility loci in the Taiwanese as compared to populations of European descent and shed significant light on the etiology of oral cancer in Taiwan.

Keywords

Humans, Genome-Wide Association Study, Genetic Predisposition to Disease, Taiwan, Mouth Neoplasms, Genetic Loci, Histocompatibility Antigens Class I, Polymorphism, Single Nucleotide, Case-Control Studies, Laminin, Vesicular Transport Proteins, oral cancer, genome-wide association study, SNP, HLA, TERT, TPRS1, TMED3

DOI

10.3390/ijms24032789

PMID

36769103

PMCID

PMC9917812

PubMedCentral® Posted Date

2-1-2023

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes