Care After Premenopausal Risk-Reducing Salpingo-Oophorectomy in High-Risk Women: Scoping Review and International Consensus Recommendations

Authors

Denise R Nebgen
Susan M Domchek
Joanne Kotsopoulos
Joanne A de Hullu
Emma J Crosbie
Vincent Singh Paramanandam
Monique M A Brood-van Zanten
Barbara M Norquist
Theresa Guise
Serge Rozenberg
Allison W Kurian
Holly J Pederson
Nese Yuksel
Rachel Michaelson-Cohen
Sharon L Bober
Agnaldo Lopes da Silva Filho
Nora Johansen
F Guidozzi
D Gareth Evans
Usha Menon
Sheryl A Kingsberg
C Bethan Powell
Giovanni Grandi
Claudia Marchetti
Michelle Jacobson
Donal J Brennan
Martha Hickey

Publication Date

11-1-2023

Journal

BJOG

Abstract

Women at high inherited risk of ovarian cancer are offered risk-reducing salpingo-oophorectomy (RRSO) from age 35 to 45 years. Although potentially life-saving, RRSO may induce symptoms that negatively affect quality of life and impair long-term health. Clinical care following RRSO is often suboptimal. This scoping review describes how RRSO affects short- and long-term health and provides evidence-based international consensus recommendations for care from preoperative counselling to long-term disease prevention. This includes the efficacy and safety of hormonal and non-hormonal treatments for vasomotor symptoms, sleep disturbance and sexual dysfunction and effective approaches to prevent bone and cardiovascular disease.

Keywords

Female, Humans, Adult, Middle Aged, Salpingo-oophorectomy, Quality of Life, Consensus, Premenopause, Ovarian Neoplasms, Ovariectomy, Genetic Predisposition to Disease, BRCA1, BRCA2, early menopause, hormone replacement therapy, hot flushes, ovarian cancer, risk-reducing salpingo-oophorectomy, sexual function, surgical menopause

DOI

10.1111/1471-0528.17511

PMID

37132126

PMCID

PMC7617419

PubMedCentral® Posted Date

2-24-2025

PubMedCentral® Full Text Version

Author MSS

Published Open-Access

yes