Faculty, Staff and Student Publications
Publication Date
6-1-2024
Journal
Expert Opinion on Drug Delivery
Abstract
Introduction: Understanding the interactions between administered nanoparticles and the liver is crucial for developing safe and effective nanomedicines. As the liver can sequester up to 99% of these particles due to its major phagocytic role, understanding these interactions is vital for clinical translation.
Areas covered: This review highlights recent studies on nanoparticle-liver interactions, including the influence of nanoparticle physicochemical properties on delivery, strategies to enhance delivery efficiency by modulating liver Kupffer cells, and their potential for treating certain hepatic diseases. Additionally, we discuss how aging impacts the liver's phagocytic functions.
Expert opinion: While liver accumulation can hinder nanomedicine safety and effectiveness, it also presents opportunities for treating certain liver diseases. A thorough understanding of nanoparticle-liver interactions is essential for advancing the clinical application of nanomedicines.
Keywords
Humans, Nanomedicine, Nanoparticles, Animals, Liver, Liver Diseases, Kupffer Cells, Drug Delivery Systems, Aging, Phagocytosis, Nanomedicine, nanoparticle, drug delivery, phagocytic clearance, liver
DOI
10.1080/17425247.2024.2375400
PMID
38946471
PMCID
PMC11281865
PubMedCentral® Posted Date
7-27-2024
PubMedCentral® Full Text Version
Author MSS
Published Open-Access
yes
Included in
Bioinformatics Commons, Biomedical Informatics Commons, Genetic Phenomena Commons, Medical Genetics Commons, Nanomedicine Commons, Oncology Commons