Faculty, Staff and Student Publications
Publication Date
5-1-2025
Journal
American Journal of Respiratory and Critical Care Medicine
Abstract
Patients with idiopathic pulmonary fibrosis and lung fibrosis secondary to infections such as influenza A and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have limited treatment options outside of supportive therapy and lung transplantation. Multiple lung stem cell populations have been implicated in the pathogenesis of lung fibrosis, and more progenitor cell populations continue to be discovered and characterized. In this review, we summarize the functions and differentiation pathways of various cells that constitute the lung epithelium. We then focus on two subpopulations of KRT5
Keywords
Humans, Animals, Idiopathic Pulmonary Fibrosis, Lung, Pulmonary Fibrosis, Cell Differentiation, COVID-19, Stem Cells, Alveolar Epithelial Cells, Epithelium, SARS-CoV-2
DOI
10.1165/rcmb.2024-0372TR
PMID
39642382
PMCID
PMC12051923
PubMedCentral® Posted Date
12-6-2024
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Included in
Bioinformatics Commons, Biomedical Informatics Commons, Genetic Phenomena Commons, Medical Genetics Commons, Oncology Commons