Strategies for the Development of Metalloimmunotherapies

Authors

Xiaoqi Sun
Xingwu Zhou
Xiaoyue Shi
Omar A Abed
Xinran An
Yu Leo Lei
James J Moon

Publication Date

9-1-2024

Journal

Nature Biomedical Engineering

Abstract

Metal ions play crucial roles in the regulation of immune pathways. In fact, metallodrugs have a long record of accomplishment as effective treatments for a wide range of diseases. Here we argue that the modulation of interactions of metal ions with molecules and cells involved in the immune system forms the basis of a new class of immunotherapies. By examining how metal ions modulate the innate and adaptive immune systems, as well as host-microbiota interactions, we discuss strategies for the development of such metalloimmunotherapies for the treatment of cancer and other immune-related diseases.

Keywords

Humans, Immunotherapy, Neoplasms, Animals, Metals, Immunity, Innate, Adaptive Immunity

DOI

10.1038/s41551-024-01221-7

PMID

38914800

PMCID

PMC11410547

PubMedCentral® Posted Date

3-1-2025

PubMedCentral® Full Text Version

Author MSS

Published Open-Access

yes