
Faculty, Staff and Student Publications
Publication Date
9-1-2024
Journal
Nature Biomedical Engineering
Abstract
Metal ions play crucial roles in the regulation of immune pathways. In fact, metallodrugs have a long record of accomplishment as effective treatments for a wide range of diseases. Here we argue that the modulation of interactions of metal ions with molecules and cells involved in the immune system forms the basis of a new class of immunotherapies. By examining how metal ions modulate the innate and adaptive immune systems, as well as host-microbiota interactions, we discuss strategies for the development of such metalloimmunotherapies for the treatment of cancer and other immune-related diseases.
Keywords
Humans, Immunotherapy, Neoplasms, Animals, Metals, Immunity, Innate, Adaptive Immunity
DOI
10.1038/s41551-024-01221-7
PMID
38914800
PMCID
PMC11410547
PubMedCentral® Posted Date
3-1-2025
PubMedCentral® Full Text Version
Author MSS
Published Open-Access
yes
Included in
Bioinformatics Commons, Biomedical Informatics Commons, Genetic Phenomena Commons, Medical Genetics Commons, Oncology Commons