Faculty, Staff and Student Publications
Publication Date
8-31-2023
Journal
Cell
Abstract
Post-translational modifications (PTMs) play key roles in regulating cell signaling and physiology in both normal and cancer cells. Advances in mass spectrometry enable high-throughput, accurate, and sensitive measurement of PTM levels to better understand their role, prevalence, and crosstalk. Here, we analyze the largest collection of proteogenomics data from 1,110 patients with PTM profiles across 11 cancer types (10 from the National Cancer Institute's Clinical Proteomic Tumor Analysis Consortium [CPTAC]). Our study reveals pan-cancer patterns of changes in protein acetylation and phosphorylation involved in hallmark cancer processes. These patterns revealed subsets of tumors, from different cancer types, including those with dysregulated DNA repair driven by phosphorylation, altered metabolic regulation associated with immune response driven by acetylation, affected kinase specificity by crosstalk between acetylation and phosphorylation, and modified histone regulation. Overall, this resource highlights the rich biology governed by PTMs and exposes potential new therapeutic avenues.
Keywords
Humans, Acetylation, Histones, Neoplasms, Phosphorylation, Protein Processing, Post-Translational, Proteomics, Post-translational modifications, Pan-Cancer, Genomics, Transcriptomics, Mass Spectrometry, Proteomics, DNA Damage Response, Metabolism, CPTAC
DOI
10.1016/j.cell.2023.07.013
PMID
37582358
PMCID
PMC10680287
PubMedCentral® Posted Date
8-31-2024
PubMedCentral® Full Text Version
Author MSS
Graphical Abstract
Published Open-Access
yes
Included in
Bioinformatics Commons, Biomedical Informatics Commons, Genetic Phenomena Commons, Medical Genetics Commons, Oncology Commons