Hrd Effects on First-Line Adjuvant Chemotherapy and PARPi Maintenance Therapy in Chinese Ovarian Cancer Patients

Authors

Lei Li
Yu Gu
Mengpei Zhang
Xiaohua Shi
Zhe Li
Xinyun Xu
Tianqi Sun
Yu Dong
Chao Xue
Xiaoru Zhu
Ran Lv
Kai Jiao
Xuwo Ji
Li-Juan Wang
Yang Zhang
Zhiyong Liang
Ying Jin
Rutie Yin
Ming Wu
Han Liang

Publication Date

5-31-2023

Journal

NPJ Precision Oncology

Abstract

Homologous recombination deficiency (HRD) testing has been approved by FDA for selecting epithelial ovarian cancer (EOC) patients who may benefit from the first-line poly (ADP-ribose) polymerase inhibitor (PARPi) maintenance therapy. However, the effects of HRD on the clinical outcomes of first-line chemotherapy and first-line PARPi maintenance therapy have not been rigorously evaluated in Chinese EOC patients. Here, we developed an HRD assay and applied it to two large retrospectively collected Chinese EOC patient cohorts. In the first-line adjuvant chemotherapy cohort (FACT, N = 380), HRD status significantly improved PFS (median, 15.6 months vs. 9.4 months; HR, 0.688; 95% CI, 0.526-0.899; P = 0.003) and OS (median, 89.5 months vs. 60.9 months; HR, 0.636; 95% CI, 0.423-0.955; P = 0.008). In the first-line PARPi maintenance therapy cohort (FPMT, N = 83), HRD status significantly improved PFS (median, NA vs. 12 months; HR, 0.438; 95% CI, 0.201-0.957; P = 0.033) and OS (median, NA vs. NA months; HR, 0.12; 95% CI, 0.029-0.505; P = 0.001). Our results demonstrate that HRD status is a significant predictor for PFS and OS in both first-line chemotherapy and first-line PARPi maintenance therapy, providing strong real-world evidence for conducting genetic testing and improving clinical recommendations for Chinese EOC patients.

Keywords

Predictive markers, Gynaecological cancer

DOI

10.1038/s41698-023-00402-y

PMID

37258600

PMCID

PMC10232447

PubMedCentral® Posted Date

5-31-2023

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes