Single-Cell Dissection of Tumor Microenvironmental Response and Resistance to Cancer Therapy

Authors

Yikai Luo
Han Liang

Publication Date

10-1-2023

Journal

Trend in Genetics

Abstract

Cancer treatment strategies have evolved significantly over the years, with chemotherapy, targeted therapy, and immunotherapy as major pillars. Each modality leads to unique treatment outcomes by interacting with the tumor microenvironment (TME), which imposes a fundamental selective pressure on cancer progression. The advent of single-cell profiling technologies has revolutionized our understanding of the intricate and heterogeneous nature of the TME at an unprecedented resolution. This review delves into the commonalities and differential manifestations of how cancer therapies reshape the microenvironment in diverse cancer types. We highlight how groundbreaking immune checkpoint blockade (ICB) strategies alone or in combination with tumor-targeting treatments are endowed with comprehensive mechanistic insights when decoded at the single-cell level, aiming to drive forward future research directions on personalized treatments.

Keywords

Tumor Microenvironment, Technology, Neoplasms, Single-cell Genomics, Tumor Microenvironment, Combination Therapy, Therapeutic Response

DOI

10.1016/j.tig.2023.07.005

PMID

37658004

PMCID

PMC10529478

PubMedCentral® Posted Date

10-1-2024

PubMedCentral® Full Text Version

Author MSS

Published Open-Access

yes