Decoding the Regulatory Roles of Non-coding RNAs in Cellular Metabolism and Disease

Authors

Yuru Zong
Xuliang Wang
Bing Cui
Xiaowei Xiong
Andrew Wu
Chunru Lin
Yaohua Zhang

Publication Date

6-7-2023

Journal

Molecular Therapy

Abstract

Non-coding RNAs, including long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs), are being studied extensively in a variety of fields. Their roles in metabolism have received increasing attention in recent years but are not yet clear. The regulation of glucose, fatty acid, and amino acid metabolism is an imperative physiological process that occurs in living organisms and takes part in cancer and cardiovascular diseases. Here, we summarize the important roles played by non-coding RNAs in glucose metabolism, fatty acid metabolism, and amino acid metabolism, as well as the mechanisms involved. We also summarize the therapeutic advances for non-coding RNAs in diseases such as obesity, cardiovascular disease, and some metabolic diseases. Overall, non-coding RNAs are indispensable factors in metabolism and have a significant role in the three major metabolisms, which may be exploited as therapeutic targets in the future.

Keywords

MicroRNAs, RNA, Circular, RNA, Long Noncoding, Fatty Acids, Amino Acids

DOI

10.1016/j.ymthe.2023.04.012

PMID

37113055

PMCID

PMC10277898

PubMedCentral® Posted Date

4-27-2023

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes