Identification of Hypoxia-ALCAMhigh Macrophage- Exhausted T Cell Axis in Tumor Microenvironment Remodeling for Immunotherapy Resistance

Authors

Zhenzhen Xun
Huanran Zhou
Mingyi Shen
Yao Liu
Chengcao Sun
Yanhua Du
Zhou Jiang
Liuqing Yang
Qing Zhang
Chunru Lin
Qingsong Hu
Youqiong Ye
Leng Han

Publication Date

9-1-2024

Journal

Advanced Science

Abstract

Although hypoxia is known to be associated with immune resistance, the adaptability to hypoxia by different cell populations in the tumor microenvironment and the underlying mechanisms remain elusive. This knowledge gap has hindered the development of therapeutic strategies to overcome tumor immune resistance induced by hypoxia. Here, bulk, single-cell, and spatial transcriptomics are integrated to characterize hypoxia associated with immune escape during carcinogenesis and reveal a hypoxia-based intercellular communication hub consisting of malignant cells, ALCAM

Keywords

Tumor Microenvironment, Immunotherapy, Macrophages, Mice, Animals, Humans, CD8-Positive T-Lymphocytes, Hypoxia-Inducible Factor 1, alpha Subunit, Hypoxia, Disease Models, Animal, Cell Line, Tumor, Neoplasms

DOI

10.1002/advs.202309885

PMID

38956900

PMCID

PMC11434037

PubMedCentral® Posted Date

7-2-2024

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes