The Abscopal Effect in Patients With Cancer Receiving Immunotherapy

Authors

Blessie Elizabeth Nelson
Jacob J Adashek
Steven H Lin
Vivek Subbiah

Publication Date

4-14-2023

Journal

Medicine

Abstract

Interest in the abscopal effect has been rekindled over the past decade with the advent of immunotherapy. Although purportedly elusive, this phenomenon is being increasingly reported. Venturing further using a multimodality approach with an array of systemic agents and unconventional modalities is direly needed. In this perspective, we describe the fundamentals of abscopal responses (ARs), explore combinations with systemic therapies that hold promise in eliciting ARs, and reconnoiter unconventional modalities that may induce ARs. Finally, we scrutinize prospective agents and modalities that exhibit preclinical ability to elicit ARs and discuss prognostic biomarkers, their limitations, and pathways of abscopal resistance for reproducibility.

Keywords

Humans, Prospective Studies, Reproducibility of Results, Immunotherapy, Combined Modality Therapy, Neoplasms, abscopal, cancer, nanoparticle therapy, radionuclide therapy, systemic therapy

DOI

10.1016/j.medj.2023.02.003

PMID

36893753

PMCID

PMC10116408

PubMedCentral® Posted Date

4-20-2023

PubMedCentral® Full Text Version

Author MSS

Published Open-Access

yes