
Faculty, Staff and Student Publications
Publication Date
4-14-2023
Journal
Medicine
Abstract
Interest in the abscopal effect has been rekindled over the past decade with the advent of immunotherapy. Although purportedly elusive, this phenomenon is being increasingly reported. Venturing further using a multimodality approach with an array of systemic agents and unconventional modalities is direly needed. In this perspective, we describe the fundamentals of abscopal responses (ARs), explore combinations with systemic therapies that hold promise in eliciting ARs, and reconnoiter unconventional modalities that may induce ARs. Finally, we scrutinize prospective agents and modalities that exhibit preclinical ability to elicit ARs and discuss prognostic biomarkers, their limitations, and pathways of abscopal resistance for reproducibility.
Keywords
Humans, Prospective Studies, Reproducibility of Results, Immunotherapy, Combined Modality Therapy, Neoplasms, abscopal, cancer, nanoparticle therapy, radionuclide therapy, systemic therapy
DOI
10.1016/j.medj.2023.02.003
PMID
36893753
PMCID
PMC10116408
PubMedCentral® Posted Date
4-20-2023
PubMedCentral® Full Text Version
Author MSS
Published Open-Access
yes
Included in
Bioinformatics Commons, Biomedical Informatics Commons, Genetic Phenomena Commons, Immunotherapy Commons, Medical Genetics Commons, Oncology Commons