Faculty, Staff and Student Publications
Publication Date
1-4-2024
Journal
Clinical Chemistry
Abstract
Background: Increasing evidence implicates microbiome involvement in the development and progression of pancreatic ductal adenocarcinoma (PDAC). Studies suggest that reflux of gut or oral microbiota can lead to colonization in the pancreas, resulting in dysbiosis that culminates in release of microbial toxins and metabolites that potentiate an inflammatory response and increase susceptibility to PDAC. Moreover, microbe-derived metabolites can exert direct effector functions on precursors and cancer cells, as well as other cell types, to either promote or attenuate tumor development and modulate treatment response.
Content: The occurrence of microbial metabolites in biofluids thereby enables risk assessment and prognostication of PDAC, as well as having potential for design of interception strategies. In this review, we first highlight the relevance of the microbiome for progression of precancerous lesions in the pancreas and, using liquid chromatography-mass spectrometry, provide supporting evidence that microbe-derived metabolites manifest in pancreatic cystic fluid and are associated with malignant progression of intraductal papillary mucinous neoplasm(s). We secondly summarize the biomarker potential of microbe-derived metabolite signatures for (a) identifying individuals at high risk of developing or harboring PDAC and (b) predicting response to treatment and disease outcomes.
Summary: The microbiome-derived metabolome holds considerable promise for risk assessment and prognostication of PDAC.
Keywords
Humans, Pancreatic Neoplasms, Carcinoma, Pancreatic Ductal, Risk Assessment, Metabolome, Microbiota
DOI
10.1093/clinchem/hvad186
PMID
38175578
PMCID
PMC11836914
PubMedCentral® Posted Date
2-19-2025
PubMedCentral® Full Text Version
Author MSS
Published Open-Access
yes
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