
Faculty, Staff and Student Publications
Publication Date
5-1-2024
Journal
Cancer Journal
Abstract
Imaging glucose metabolism with [18F]fluorodeoxyglucose positron emission tomography has transformed the diagnostic and treatment algorithms of numerous malignancies in clinical practice. The cancer phenotype, though, extends beyond dysregulation of this single pathway. Reprogramming of other pathways of metabolism, as well as altered perfusion and hypoxia, also typifies malignancy. These features provide other opportunities for imaging that have been developed and advanced into humans. In this review, we discuss imaging metabolism, perfusion, and hypoxia in cancer, focusing on the underlying biology to provide context. We conclude by highlighting the ability to image multiple facets of biology to better characterize cancer and guide targeted treatment.
Keywords
Humans, Fluorodeoxyglucose F18, Neoplasms, Positron-Emission Tomography, Radiopharmaceuticals, Hypoxia, Metabolism, Perfusion, Hypoxia, Positron-emission tomography, Fluorodeoxyglucose F18
DOI
10.1097/PPO.0000000000000716
PMID
38753750
PMCID
PMC11101148
PubMedCentral® Posted Date
1-1-2025
PubMedCentral® Full Text Version
Author MSS
Published Open-Access
yes
Included in
Bioinformatics Commons, Biomedical Informatics Commons, Genetic Phenomena Commons, Medical Genetics Commons, Oncology Commons