PET Imaging of Metabolism, Perfusion, and Hypoxia: FDG and Beyond

Authors

Austin R Pantel
Seong-Woo Bae
Elizabeth J Li
Sophia R O'Brien
H Charles Manning

Publication Date

5-1-2024

Journal

Cancer Journal

Abstract

Imaging glucose metabolism with [18F]fluorodeoxyglucose positron emission tomography has transformed the diagnostic and treatment algorithms of numerous malignancies in clinical practice. The cancer phenotype, though, extends beyond dysregulation of this single pathway. Reprogramming of other pathways of metabolism, as well as altered perfusion and hypoxia, also typifies malignancy. These features provide other opportunities for imaging that have been developed and advanced into humans. In this review, we discuss imaging metabolism, perfusion, and hypoxia in cancer, focusing on the underlying biology to provide context. We conclude by highlighting the ability to image multiple facets of biology to better characterize cancer and guide targeted treatment.

Keywords

Humans, Fluorodeoxyglucose F18, Neoplasms, Positron-Emission Tomography, Radiopharmaceuticals, Hypoxia, Metabolism, Perfusion, Hypoxia, Positron-emission tomography, Fluorodeoxyglucose F18

DOI

10.1097/PPO.0000000000000716

PMID

38753750

PMCID

PMC11101148

PubMedCentral® Posted Date

1-1-2025

PubMedCentral® Full Text Version

Author MSS

Published Open-Access

yes