Adjuvant Radiation Therapy in Desmoplastic Melanoma: A Scoping Review

Authors

Christina Setareh Sharafi
B Ashleigh Guadagnolo
Kelly C Nelson
Devarati Mitra

Publication Date

11-19-2024

Journal

Cancers

Abstract

Desmoplastic melanoma (DM) is an uncommon subtype of cutaneous melanoma that presents distinct diagnostic and treatment challenges. This review aims to explore the role of adjuvant radiation therapy (RT) in managing DM. To evaluate this question, we reviewed relevant published reports on DM and its treatment and synthesized these findings. It was found that the clinical behavior of DM varies significantly based on its classification as either "pure" DM (pDM, ≥90% desmoplastic features) or mixed DM (mDM, ≤90% desmoplastic features). Patients with pDM have a uniquely high risk of local recurrence but a relatively lower likelihood of nodal disease. Recent studies question the necessity of sentinel lymph node biopsy for pDM patients while illustrating impressive response rates to immune checkpoint inhibition. Most data supporting adjuvant RT predate these changes in surgical management and systemic therapy, yet consistently demonstrate that adjuvant RT reduces the absolute risk of local recurrence by >50%, without significant long-term toxicity. Thus, the existing literature continues to support the conclusion that adjuvant RT effectively reduces the likelihood of local recurrence in pDM patients. Although evolving surgical and systemic therapies are reshaping treatment approaches, adjuvant RT should remain a standard of care.

Keywords

desmoplastic melanoma, immunotherapy, local control, radiation therapy

DOI

10.3390/cancers16223874

PMID

39594829

PMCID

PMC11593037

PubMedCentral® Posted Date

11-19-2024

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes