Faculty, Staff and Student Publications
Publication Date
1-17-2023
Journal
Cell Reports Medicine
Abstract
In a recent issue of Cancer Cell, Amodio and colleagues report an interesting method of modulating immunosurveillance in colorectal tumors with DNA mismatch repair (MMR) heterogeneity.1 By pharmacologically enriching the MMR deficient (MMRd) component using 6-thioguanine, they demonstrate improved tumor control in murine models.
Keywords
Animals, Mice, DNA Mismatch Repair, Colorectal Neoplasms, Thioguanine
DOI
10.1016/j.xcrm.2022.100908
PMID
36652917
PMCID
PMC9873932
PubMedCentral® Posted Date
1-17-2023
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Included in
Bioinformatics Commons, Biomedical Informatics Commons, Genetic Phenomena Commons, Medical Genetics Commons, Oncology Commons