Regression Analysis of General Mixed Recurrent Event Data

Authors

Ryan Sun
Dayu Sun
Liang Zhu
Jianguo Sun

Publication Date

10-1-2023

Journal

Lifetime Data Analysis

Abstract

In modern biomedical datasets, it is common for recurrent outcomes data to be collected in an incomplete manner. More specifically, information on recurrent events is routinely recorded as a mixture of recurrent event data, panel count data, and panel binary data; we refer to this structure as general mixed recurrent event data. Although the aforementioned data types are individually well-studied, there does not appear to exist an established approach for regression analysis of the three component combination. Often, ad-hoc measures such as imputation or discarding of data are used to homogenize records prior to the analysis, but such measures lead to obvious concerns regarding robustness, loss of efficiency, and other issues. This work proposes a maximum likelihood regression estimation procedure for the combination of general mixed recurrent event data and establishes the asymptotic properties of the proposed estimators. In addition, we generalize the approach to allow for the existence of terminal events, a common complicating feature in recurrent event analysis. Numerical studies and application to the Childhood Cancer Survivor Study suggest that the proposed procedures work well in practical situations.

Keywords

Humans, Child, Regression Analysis, Computer Simulation, Event history study, Panel binary data, Panel count data, Recurrent event data, Terminal event

DOI

10.1007/s10985-023-09604-9

PMID

37438585

PMCID

PMC11334736

PubMedCentral® Posted Date

10-1-2024

PubMedCentral® Full Text Version

Author MSS

Published Open-Access

yes