Faculty, Staff and Student Publications

Publication Date

9-6-2022

Journal

Cell Reports

Abstract

Functional implication of stromal heterogeneity in the prostate remains incompletely understood. Using lineage tracing and light-sheet imaging, we show that some fibroblast cells at the mouse proximal prostatic ducts and prostatic urethra highly express Lgr5. Genetic ablation of these anatomically restricted stromal cells, but not nonselective ablation of prostatic stromal cells, rapidly induces prostate epithelial turnover and dedifferentiation that are reversed following spontaneous restoration of the Lgr5

Keywords

Animals, Homeostasis, Male, Mice, Prostate, Receptors, G-Protein-Coupled, Signal Transduction, Stromal Cells, CP: Cell biology, CP: Developmental biology, Lgr5, MAPK, mechanoforce, prostate, stromal cells

DOI

10.1016/j.celrep.2022.111313

PMID

36070687

PMCID

PMC9491244

PubMedCentral® Posted Date

9-21-2022

PubMedCentral® Full Text Version

Author MSS

Published Open-Access

yes

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.