Ablating Lgr5-Expressing Prostatic Stromal Cells Activates the Erk-Mediated Mechanosensory Signaling and Disrupts Prostate Tissue Homeostasis

Authors

Xing Wei
Li Zhang
Yiqun Zhang
Cody Cooper
Chris Brewer
Chia-Feng Tsai
Yi-Ting Wang
Micah Glaz
Hunter B Wessells
Jianwen Que
Mark A Titus
Vincenzino Cirulli
Adam Glaser
Tao Liu
Nicholas P Reder
Chad J Creighton
Li Xin

Publication Date

9-6-2022

Journal

Cell Reports

Abstract

Functional implication of stromal heterogeneity in the prostate remains incompletely understood. Using lineage tracing and light-sheet imaging, we show that some fibroblast cells at the mouse proximal prostatic ducts and prostatic urethra highly express Lgr5. Genetic ablation of these anatomically restricted stromal cells, but not nonselective ablation of prostatic stromal cells, rapidly induces prostate epithelial turnover and dedifferentiation that are reversed following spontaneous restoration of the Lgr5

Keywords

Animals, Homeostasis, Male, Mice, Prostate, Receptors, G-Protein-Coupled, Signal Transduction, Stromal Cells, CP: Cell biology, CP: Developmental biology, Lgr5, MAPK, mechanoforce, prostate, stromal cells

DOI

10.1016/j.celrep.2022.111313

PMID

36070687

PMCID

PMC9491244

PubMedCentral® Posted Date

9-21-2022

PubMedCentral® Full Text Version

Author MSS

Published Open-Access

yes