
Faculty, Staff and Student Publications
Publication Date
9-6-2022
Journal
Cell Reports
Abstract
Functional implication of stromal heterogeneity in the prostate remains incompletely understood. Using lineage tracing and light-sheet imaging, we show that some fibroblast cells at the mouse proximal prostatic ducts and prostatic urethra highly express Lgr5. Genetic ablation of these anatomically restricted stromal cells, but not nonselective ablation of prostatic stromal cells, rapidly induces prostate epithelial turnover and dedifferentiation that are reversed following spontaneous restoration of the Lgr5
Keywords
Animals, Homeostasis, Male, Mice, Prostate, Receptors, G-Protein-Coupled, Signal Transduction, Stromal Cells, CP: Cell biology, CP: Developmental biology, Lgr5, MAPK, mechanoforce, prostate, stromal cells
DOI
10.1016/j.celrep.2022.111313
PMID
36070687
PMCID
PMC9491244
PubMedCentral® Posted Date
9-21-2022
PubMedCentral® Full Text Version
Author MSS
Published Open-Access
yes
Included in
Bioinformatics Commons, Biomedical Informatics Commons, Genetic Phenomena Commons, Medical Genetics Commons, Oncology Commons