Faculty, Staff and Student Publications
Publication Date
9-1-2022
Journal
Gastroenterology Clinics of North America
Abstract
The human microbiome has been recognized as increasingly important to health and disease. This is especially prescient in the development of various cancers, their progression, and the microbiome's modulation of various anticancer therapeutics. Mechanisms behind these interactions have been increasingly well described through modulation of the host immune system as well as induction of genetic changes and local inactivation of cancer therapeutics. Here, we review these associations for a variety of gastrointestinal malignancies as well as contemporary strategies proposed to leverage these associations to improve cancer treatment outcomes.
Keywords
Gastrointestinal Neoplasms, Humans, Immune System, Microbiota, Colorectal adenocarcinoma, Gastric adenocarcinoma, Microbiome, Pancreatic ductal adenocarcinoma, Tumor microenvironment
DOI
10.1016/j.gtc.2022.06.007
PMID
36153116
PMCID
PMC11833749
PubMedCentral® Posted Date
2-18-2025
PubMedCentral® Full Text Version
Author MSS
Published Open-Access
yes
Included in
Bioinformatics Commons, Biomedical Informatics Commons, Gastroenterology Commons, Genetic Phenomena Commons, Medical Genetics Commons, Oncology Commons