Faculty, Staff and Student Publications
Publication Date
8-1-2022
Journal
JCO Precision Oncology
Abstract
PURPOSE: Anaplastic thyroid carcinoma (ATC) uniformly present with aggressive disease, but the mutational landscape of tumors varies. We aimed to determine whether tumor mutations affect survival outcomes in ATC.
MATERIALS AND METHODS: Patients who underwent mutation sequencing using targeted gene panels between 2005 and 2019 at a tertiary referral center were included. Associations between mutation status and survival outcomes were assessed using Cox proportional hazards models.
RESULTS: A total of 202 patients were included, where 122 died of ATC (60%). The median follow-up was 31 months (interquartile range, 18-45 months). The most common mutations were in
CONCLUSION: Mutation analysis provides prognostic information in ATC and should be incorporated into routine clinical care.
Keywords
Humans, Mutation, Proto-Oncogene Proteins B-raf, Thyroid Cancer, Papillary, Thyroid Carcinoma, Anaplastic, Thyroid Neoplasms
DOI
10.1200/PO.21.00504
PMID
35977347
PMCID
PMC10530586
PubMedCentral® Posted Date
8-17-2022
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Included in
Bioinformatics Commons, Biomedical Informatics Commons, Genetic Phenomena Commons, Medical Genetics Commons, Oncology Commons