Faculty, Staff and Student Publications
Publication Date
3-1-2023
Journal
Head & Neck
Abstract
Background: Advanced thyroid disease involving the mediastinum may be managed surgically with a combined transcervical and transthoracic approach. Contemporary analysis of this infrequently encountered cohort will aid the multidisciplinary team in personalizing treatment approaches.
Methods: Retrospective review of patients undergoing combined transcervical and transthoracic surgery for thyroid cancer at a single high-volume institution from 1994 to 2015.
Results: Thirty-eight patients with median age 59 years (range 28-76) underwent surgery without perioperative mortality. Most patients had primary disease. A majority had distant metastases outside the mediastinum but had locoregionally curable disease. Common complications were temporary (39%) and permanent (18%) hypoparathyroidism, and wound infection (13%). One-year overall survival was 84%; 1-year locoregional disease-free survival was 64%. Median time to locoregional recurrence was 36 months. Only esophageal invasion was associated with worse oncologic outcomes.
Conclusions: Combined transcervical and transthoracic surgery for advanced thyroid cancer can be performed without mortality and with acceptable morbidity.
Keywords
Humans, Adult, Middle Aged, Aged, Neoplasm Recurrence, Local, Neck, Thyroid Neoplasms, Thyroid Diseases, Retrospective Studies, Thyroidectomy, advanced thyroid cancer, endocrine surgery, manubriectomy, outcomes, sternotomy
DOI
10.1002/hed.27260
PMID
36524701
PMCID
PMC12049177
PubMedCentral® Posted Date
5-3-2025
PubMedCentral® Full Text Version
Author MSS
Published Open-Access
yes
Included in
Bioinformatics Commons, Biomedical Informatics Commons, Genetic Phenomena Commons, Medical Genetics Commons, Oncology Commons