Faculty, Staff and Student Publications

Publication Date

4-24-2023

Journal

International Journal of Molecular Sciences

Abstract

The identification of biomarkers plays a crucial role in personalized medicine, both in the clinical and research settings. However, the contrast between predictive and prognostic biomarkers can be challenging due to the overlap between the two. A prognostic biomarker predicts the future outcome of cancer, regardless of treatment, and a predictive biomarker predicts the effectiveness of a therapeutic intervention. Misclassifying a prognostic biomarker as predictive (or vice versa) can have serious financial and personal consequences for patients. To address this issue, various statistical and machine learning approaches have been developed. The aim of this study is to present an in-depth analysis of recent advancements, trends, challenges, and future prospects in biomarker identification. A systematic search was conducted using PubMed to identify relevant studies published between 2017 and 2023. The selected studies were analyzed to better understand the concept of biomarker identification, evaluate machine learning methods, assess the level of research activity, and highlight the application of these methods in cancer research and treatment. Furthermore, existing obstacles and concerns are discussed to identify prospective research areas. We believe that this review will serve as a valuable resource for researchers, providing insights into the methods and approaches used in biomarker discovery and identifying future research opportunities.

Keywords

Humans, Biomarkers, Tumor, Prognosis, Prospective Studies, Biomarkers, Precision Medicine, Machine Learning, Neoplasms, biomarker discovery, deep learning, feature selection, machine learning, personalized medicine, predictive biomarker, prognostic biomarker, subgroup identification

DOI

10.3390/ijms24097781

PMID

37175487

PMCID

PMC10178491

PubMedCentral® Posted Date

4-24-2023

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes

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