Faculty, Staff and Student Publications
Publication Date
8-20-2024
Journal
Cell Reports Medicine
Abstract
Nationwide estimates of the impact of common modifiable risk factors on mortality remain crucial. We aim to assess the influence of social determinants, lifestyle, and metabolic factors on mortality in 174,004 adults aged ≥40 years from the China Cardiometabolic Disease and Cancer Cohort (4C) Study. We reveal that 17 modifiable factors are independently associated with mortality, accounting for 64.8% of all-cause mortality, 77.4% of cardiovascular mortality, and 44.8% of cancer mortality. Low education emerges as the leading factor for both all-cause and cancer mortality, while hypertension is predominant for cardiovascular mortality. Moreover, low gross domestic product per capita and high ambient particulate matter with a diameter of < 2.5 μm (PM2.5) air pollution account for 7.8% and 4.3% for all-cause mortality, respectively, using a different method. Gender-specific analyses reveal distinct patterns, with women's mortality primarily associated with social determinants and men exhibiting stronger associations with lifestyle factors. Targeted health interventions are essential to mitigate mortality risks effectively in China.
Keywords
Humans, Male, Life Style, Female, China, Middle Aged, Prospective Studies, Adult, Aged, Risk Factors, Social Determinants of Health, Neoplasms, Cardiovascular Diseases, East Asian People, CVD mortality, all-cause mortality, cancer mortality, lifestyle, metabolic factors, social determinants
DOI
10.1016/j.xcrm.2024.101656
PMID
39067445
PMCID
PMC11384959
PubMedCentral® Posted Date
7-26-2024
PubMedCentral® Full Text Version
Post-print
Graphical Abstract
Published Open-Access
yes
Included in
Bioinformatics Commons, Biomedical Informatics Commons, Genetic Phenomena Commons, Medical Genetics Commons, Oncology Commons