Clinical Outcomes of Patients with Recurrent Microsatellite-Stable Endometrial Cancer in Early-Phase Immunotherapy Clinical Trials

Authors

Jeffrey A How
Amir A Jazaeri
Siqing Fu
Jordi Rodon Ahnert
Jing Gong
Bettzy Stephen
Hanna Ferreira Dalla Pria
Priya Bhosale
Amber Johnson
Ying Yuan
Funda Meric-Bernstam
Aung Naing

Publication Date

7-29-2022

Journal

Cancers

Abstract

Recurrent microsatellite stable (MSS) endometrial cancer has poor response to conventional therapy and limited efficacy with immune checkpoint monotherapy. We conducted a retrospective study of recurrent MSS endometrial cancer patients enrolled in immunotherapy-based clinical trials at MD Anderson Cancer Center between 1 January 2010 and 31 December 2019. Patients were evaluated for radiologic response using RECIST 1.1 criteria, progression-free survival (PFS), and overall survival (OS). Thirty-five patients were treated with immune checkpoint inhibitors: 8 with monotherapy, 17 with immunotherapy (IO) in combination with another IO-only, and 10 with IO in combination with non-IO therapy. Among those treated with combination IO plus non-IO therapy, one had a partial response but 50% had clinical benefit. Patients who received combination IO plus non-IO therapy had improved PFS compared to those who received monotherapy (HR 0.56, 95% CI 0.33-0.97; p = 0.037) or combination IO-only therapy (HR 0.36, 95% CI 0.15-0.90; p = 0.028) and had improved OS when compared to monotherapy after adjusting for prior lines of therapy (HR 0.50, 95% CI 0.27-0.95; p = 0.036). The potential beneficial clinical outcomes of combination IO plus non-IO therapy in MSS endometrial cancer should be validated in a larger study.

Keywords

clinical trials, endometrial cancer, immune checkpoint inhibitors, immunotherapy, microsatellite stable

DOI

10.3390/cancers14153695

PMID

35954359

PMCID

PMC9367373

PubMedCentral® Posted Date

7-29-2022

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes