Racial Differences in Systemic Immune Parameters in Individuals With Lung Cancer

Authors

Mitchell S von Itzstein
Jialiang Liu
Hong Mu-Mosley
Farjana Fattah
Jason Y Park
Jeffrey A SoRelle
J David Farrar
Mary E Gwin
David Hsiehchen
Yvonne Gloria-McCutchen
Edward K Wakeland
Suzanne Cole
Sheena Bhalla
Radhika Kainthla
Igor Puzanov
Benjamin Switzer
Gregory A Daniels
Yousef Zakharia
Montaser Shaheen
Jianjun Zhang
Yang Xie
David E Gerber

Publication Date

1-1-2025

Journal

JTO Clinical and Research Reports

Abstract

Introduction: Racial and ethnic disparities in the presentation and outcomes of lung cancer are widely known. To evaluate potential factors contributing to these observations, we measured systemic immune parameters in Black and White patients with lung cancer.

Methods: Patients scheduled to receive cancer immunotherapy were enrolled in a multi-institutional prospective biospecimen collection registry. Clinical and demographic information were obtained from electronic medical records. Pretreatment peripheral blood samples were collected and analyzed for cytokines using a multiplex panel and for immune cell populations using mass cytometry. Differences between Black and White patients were determined and corrected for multiple comparisons.

Results: A total of 187 patients with NSCLC (Black, 19; White, 168) were included in the analysis. Compared with White patients, Black patients had greater comorbidity (median Charlson Comorbidity Index 5 versus 3; p = 0.04) and were more likely to have received previous chemotherapy (79% versus 47%; p = 0.03). Black patients had significantly lower levels of CCL23 and CCL27 and significantly higher levels of CCL8, CXCL1, CCL26, CCL25, CCL1, IL-1b, CXCL16, and IFN-γ (all p < 0.05, false discovery rate < 0.1). Black patients also exhibited greater populations of nonclassical CD16+ monocytes, NKT-like cells, CD4+ cells, CD38+ monocytes, and CD57+ gamma delta T cells (all p < 0.05).

Conclusions: Black and White patients with lung cancer exhibit several differences in immune parameters, with Black patients exhibiting greater levels of numerous proinflammatory cytokines and cell populations. The etiology and clinical significance of these differences warrant further evaluation.

Keywords

Cytokines, Immune cells, Disparities, Immunotherapy, Lung cancer, Race

DOI

10.1016/j.jtocrr.2024.100751

PMID

39619775

PMCID

PMC11605181

PubMedCentral® Posted Date

10-19-2024

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes