Student and Faculty Publications
Publication Date
1-1-2024
Journal
Respiratory Medicine Case Reports
Abstract
Bronchiolitis obliterans (BO) is a form of graft-versus-host disease (GVHD) in the lung and manifests as moderate to severe airflow obstruction after hematopoietic stem cell transplantation (HCT). New-onset airflow obstruction on spirometry is considered diagnostic of bronchiolitis obliterans syndrome (BOS). BOS affects about 5% of all HCT recipients. In general, BO is thought of as a late complication of HCT, usually occurring after day 100 post-transplantation. However, the onset of airflow obstruction can be rapid and is most often irreversible even with treatment. We describe a patient who rapidly developed severe airflow obstruction less than one month after transplantation following the development of upper airway symptoms. Despite aggressive immunosuppression, the patient had no improvement in airflow obstruction. We hypothesize that early screening and treatment may help prevent BOS after HCT.
Keywords
Bronchiolitis obliterans syndrome, Hematopoietic cell transplantation, Handheld spirometry, Screening
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Bioinformatics Commons, Biomedical Informatics Commons, Medical Sciences Commons, Medical Specialties Commons, Respiratory Tract Diseases Commons
Comments
PMID: 38745870