Student and Faculty Publications
Publication Date
8-1-2023
Journal
JAMA Pediatrics
Abstract
IMPORTANCE: There is a paucity of pediatric-specific comparative data to guide duration of therapy recommendations in children with urinary tract infection (UTI).
OBJECTIVE: To compare the efficacy of standard-course and short-course therapy for children with UTI.
DESIGN, SETTING, PARTICIPANTS: The Short Course Therapy for Urinary Tract Infections (SCOUT) randomized clinical noninferiority trial took place at outpatient clinics and emergency departments at 2 children's hospitals from May 2012, through, August 2019. Data were analyzed from January 2020, through, February 2023. Participants included children aged 2 months to 10 years with UTI exhibiting clinical improvement after 5 days of antimicrobials.
INTERVENTION: Another 5 days of antimicrobials (standard-course therapy) or 5 days of placebo (short-course therapy).
MAIN OUTCOME MEASURES: The primary outcome, treatment failure, was defined as symptomatic UTI at or before the first follow-up visit (day 11 to 14). Secondary outcomes included UTI after the first follow-up visit, asymptomatic bacteriuria, positive urine culture, and gastrointestinal colonization with resistant organisms.
RESULTS: Analysis for the primary outcome included 664 randomized children (639 female [96%]; median age, 4 years). Among children evaluable for the primary outcome, 2 of 328 assigned to standard-course (0.6%) and 14 of 336 assigned to short-course (4.2%) had a treatment failure (absolute difference of 3.6% with upper bound 95% CI of 5.5.%). Children receiving short-course therapy were more likely to have asymptomatic bacteriuria or a positive urine culture at or by the first follow-up visit. There were no differences between groups in rates of UTI after the first follow-up visit, incidence of adverse events, or incidence of gastrointestinal colonization with resistant organisms.
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial, children assigned to standard-course therapy had lower rates of treatment failure than children assigned to short-course therapy. However, the low failure rate of short-course therapy suggests that it could be considered as a reasonable option for children exhibiting clinical improvement after 5 days of antimicrobial treatment.
TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT01595529.
Keywords
Child, Humans, Female, Child, Preschool, Duration of Therapy, Anti-Bacterial Agents, Bacteriuria, Urinary Tract Infections, Treatment Outcome
Included in
Bioinformatics Commons, Biomedical Informatics Commons, Diseases Commons, Medical Sciences Commons, Pediatrics Commons, Urology Commons
Comments
This article has been corrected. See JAMA Pediatr. 2024 April 15; 178(6): 630. See commentary "Does the SCOUT Trial Fall Short of Determining an Effective Treatment Duration for Pediatric Urinary Tract Infections?" in JAMA Pediatr, 37358846. See the letter "Nonsuperiority of Standard Therapy Compared to Short-Course Therapy in Symptomatic UTIs." in JAMA Pediatr, 37812426.
Supplementary Materials
PMID: 37358858