Publication Date

1-1-2023

Journal

Multiple Sclerosis Journal – Experimental, Translational and Clinical

Abstract

BACKGROUND: Tremor affects up to 45% of patients with Multiple Sclerosis (PwMS). Current understanding is based on insights from other neurological disorders, thus, not fully addressing the distinctive aspects of MS pathology.

OBJECTIVE: To characterize the brain white matter (WM) correlates of MS-related tremor using diffusion tensor imaging (DTI).

METHODS: In a prospective case-control study, PwMS with tremor were assessed for tremor severity and underwent MRI scans including DTI. PwMS without tremor served as matched controls. After tract selection and segmentation, the resulting diffusivity measures were used to calculate group differences and correlations with tremor severity.

RESULTS: This study included 72 PwMS. The tremor group (n = 36) exhibited significant changes in several pathways, notably in the right inferior longitudinal fasciculus (Cohen's

CONCLUSION: MS-related tremor is associated with widespread diffusivity changes in WM pathways and its severity correlates with commissural and sensory projection pathways, which suggests a role for proprioception or involvement of the dentato-rubro-olivary circuit.

Keywords

Multiple sclerosis, diffusion imaging, proprioception, tractography, tremor, white matter pathways

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